Take it seriously. Yes, you’re applying for an online job. Yes, you can do the work in your underwear, but that doesn’t mean it’s not a “real job”. You must treat it as such or they aren’t going to treat you as a serious candidate. You aren’t the only one who wants to work in their underwear. In fact, the competition online is likely higher than it is in your local area.
You can find affiliate marketing offers on sites like ClickBank, CJ.com and Rakuten LinkShare, amongst many others. Search for the right offer and ensure that you present it to the right audience and don't spam people about it. Do your marketing ethically. If you're looking for more information on effective affiliate marketing, check out Pat Flynn's Smart Passive Income website.
For some people, work just has to be in an office, factory, store, or any other environment that’s separate from home. Even a second job would have to be in a separate place. For others, a home office is a welcome place for a secondary or even a primary job. If you’re one of those people, you have some unique opportunities, but you also have some very particular challenges of working from home.
High-ticket consulting or coaching: You could sell your own high-ticket consulting or coaching products from your website. You'll still need a website, merchant account, sales funnel, lead magnet and many other items. But you can easily earn a substantial amount of money from each individual customer, making it well worth the arduous setup required.